Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein
نویسندگان
چکیده
منابع مشابه
Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
The nicotinic acetylcholine receptor (nAChR) and the acetylcholine binding protein (AChBP) are pentameric oligomers in which binding sites for nicotinic agonists and competitive antagonists are found at selected subunit interfaces. The nAChR spontaneously exists in multiple conformations associated with its activation and desensitization steps, and conformations are selectively stabilized by bi...
متن کاملStructural basis of PROTAC cooperative recognition for selective protein degradation
Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase-PROTAC-target species and its impact on target degradation selectiv...
متن کاملStructural Basis for Cooperative DNA
when the bacterial environment contains no lactose (Al-berts et al., 2002; Berg et al., 2002). The repressor functions as a dimer of two " hand " domains (Figure 1D). loop is critical for the lac operon repression (Matthews, 1992). The primary roles of CAP and LR are the opposite of Summary each other, yet the two proteins bind to DNA cooperatively (Hudson and Fried, 1990; Lewis et al., 1996). ...
متن کاملStructural basis for the RNA binding selectivity of oligonucleotide analogues containing alkylsulfide internucleoside linkages and 2'-substituted 3'-deoxyribonucleosides.
In this report we describe the synthesis of oligonucleotides containing sulfide-linked dinucleoside units, namely rT(2'OH)sdT, rT(2'OMe)sdT, dTsrU(2'OMe) and dT(2'OMe)srU(2'OMe). We also describe the interactions of such oligomers with complementary DNA and RNA targets, and provide the structural basis for their remarkable RNA binding selectivity. In all cases, the Tm values of the S/P-chimera ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1410992111